Episode 185

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Published on:

23rd Dec 2025

Hormone Replacement Therapy Decoded: Why the FDA Removed the Blackbox Warning on HRT

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Timestamps:

0:00 - FDA Lifts Blackbox Warning on HRT

1:08 - Definitions: Viralization & Androgens

3:08 - The New Landscape of Women's Health

4:46 - Gold Standard Testing: Mass-Spec

5:52 - Finding the Estrogen Sweet Spot for Men

8:07 - Testosterone Lab Ranges for Women

10:16 - Is Testosterone Safe for Women?

13:30 - Anabolic vs. Androgenic Steroids

16:56 - HRT Red Flags: Who Should Not Start

18:19 - Longevity Benefits of HRT

21:23 - Estrogen's Role in Brain Health

24:32 - Performance Impact in Young Women

33:03 - Type 2 Muscle Hypertrophy

37:06 - Monitoring Hematocrit & Safety

41:44 - Delivery: Injections vs. Gels

42:31 - How TRT Can Mask Anemia

46:36 - Impact on Cholesterol & Lipids

51:48 - Non-Negotiable Baseline Lab Panels

53:23 - Case Study: 60-Year-Old Transformation

58:15 - The Future of FDA Approval

59:06 - Can DHEA Move the Needle?

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About the Podcast

The Dr. Gabrielle Lyon Show
The Dr. Gabrielle Lyon Show promotes a healthy world, and in order to have a healthy world, we must have transparent conversations. This show is dedicated to such conversations as the listener; your education, understanding, strength, and health are the primary focus. The goal of this show is to provide you with a framework for navigating the health and wellness space and, most importantly, being the champion of your own life. Guests include highly trustworthy professionals that bring both the art and science of wellness aspects that are both physical and mental. Dr. Gabrielle Lyon is a Washington University fellowship-trained physician who serves the innovators, mavericks, and leaders in their fields, as well as working closely with the Special Operations Military. She is the founder of the Institute of Muscle-Centric Medicine® and serves patients worldwide.