Episode 169

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Published on:

1st Sep 2025

Ultimate Fat Loss Guide - Gabrielle Lyon - Mike Israetel - Layne Norton - Don Saladino

In this compilation, Dr. Gabrielle Lyon brings together the top minds in health and fitness to deliver the ultimate guide to fat loss. Featuring the best moments with Dr. Mike Israetel, Dr. Layne Norton, and Don Saladino, this video cuts through the confusion and gives you a no-nonsense, science-backed approach to transforming your body.

You’ll hear from the experts on everything from the flawed science of calories to the truth about muscle, metabolism, and modern weight loss drugs like Ozempic. This is not about fads or quick fixes—it’s a masterclass in building a sustainable, healthy body.

Dr. Mike Israetel: The fundamental principles of diet, the reality of "under-eating," and how to manage diet fatigue.

Dr. Layne Norton: The truth about flexible dieting, why calories still count, and the role of protein in weight loss.

Don Saladino: How to optimize your training for fat loss, the importance of consistency, and building a stronger mindset.

This is the only fat loss guide you'll ever need.

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Chapters

0:00 - The Protein Debate Begins

1:31 - Debunking the Flawed Science of Protein

15:00 - The Myth of "Wasted" Protein

22:42 - The Truth About the RDA & What "Deficiency" Really Means

50:41 - The Problem with Plant Proteins & Caloric Cost

1:05:22 - The 100-Gram Protein Tipping Point

1:09:10 - Carbs vs. Protein: A Metabolic Showdown

1:13:15 - How to Diagnose a Protein Deficiency

1:18:13 - Final Thoughts: The Path Forward

This episode is sponsored by:

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Disclaimer: The Dr. Gabrielle Lyon Podcast and YouTube are for general information purposes only and do not constitute the practice of medicine, nursing, or other professional health care services, including the giving of medical advice, and no doctor/patient relationship is formed. The use of information on this podcast, YouTube, or materials linked from this podcast or YouTube is at the user's own risk. The content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Users should not disregard or delay in obtaining medical advice for any medical condition they may have and should seek the assistance of their health care professional for any such conditions.

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About the Podcast

The Dr. Gabrielle Lyon Show
The Dr. Gabrielle Lyon Show promotes a healthy world, and in order to have a healthy world, we must have transparent conversations. This show is dedicated to such conversations as the listener; your education, understanding, strength, and health are the primary focus. The goal of this show is to provide you with a framework for navigating the health and wellness space and, most importantly, being the champion of your own life. Guests include highly trustworthy professionals that bring both the art and science of wellness aspects that are both physical and mental. Dr. Gabrielle Lyon is a Washington University fellowship-trained physician who serves the innovators, mavericks, and leaders in their fields, as well as working closely with the Special Operations Military. She is the founder of the Institute of Muscle-Centric Medicine® and serves patients worldwide.